Current International Research Projects
Cardio-respiratory responses in dolphins Cardiorespiratory physiology in the bottlenose dolphin before, during, and after breath-holding and restraint.
- Call
- Office of Naval Research Contracts&Grants 2015.
- Investigador principal
- Dr. Andreas Fahlman
- Role
- Individual
- Year
- 2016
The proposed work is intended to evaluate cardiorespiratory (heart rate, stroke volume, systemic and pulmoarterial pressures, respiratory flow and expired gas composition) function in a small cetacean, the bottlenose dolphin, at rest, during apnea, during recovery from apnea and during and following a stressful situation. In addition, we will use these data to extract medical biomarkers from animals that are adapted to a range of extreme physiological challenges (e.g. hypoxia, ischemia/reperfusion, atelectasis). These biomarkers may provide valuable information for human clinical medicine.
Hibbs Association between Intermittent Hypoxia and Later Respiratory Morbidity.
- Call
- NIH-R01-HL16-015
- Investigador principal
- Dr. Máximo Vento
- Role
- Consultant
- Year
- 2016
Longer term respiratory morbidity remains a major consequence of preterm birth. The hypotheses will be in Aims 1 and 2 that IH episodes at one week and one month of life are significantly associated with prolonged duration of hospitalization and respiratory support, as well as a high incidence of wheezing disorders by six months adjusted age. In Aim 3 that low serotonin levels are associated with a high incidence of IH and a prolonged recovery of respiratory effort after onset of desaturation. Finally, in Aim 4 a temporal relationship between IH episodes and markers of oxidative stress determined by urine and blood samples.
ALBINO ALBINO: Effect of allopurinol in addition to hypothermia for hypoxic-ischemic brain injury on neurocognitive outcome.
- Call
- H2020-PHC-18-2015-two-stage.
- Investigador principal
- Dr. Máximo Vento
- Role
- Participant
- Year
- 2015
This project aims to evaluate the efficacy and safety of allopurinol administered immediately after birth to near-term infants with HIE in addition to hypothermic treatment. The project will also provide information on the effect of hypothermia on pharmacokinetics of drugs with a similar metabolism as allopurinol in neonates, and develop and validate biomarkers for neonatal brain injury using advanced magnetic resonance imaging, biochemistry, and electroencephalogramms, which will then be available for future studies testing neuroprotective interventions.
COBIOPHAD Compact biophotonic platform for drug allergy diagnosis.
- Call
- H2020-ICT-28-2015.
- Investigador principal
- Dr. Dolores Hernández F. de Rojas
- Role
- Participant
- Year
- 2015
COBIOPHAD aims the development of an innovative in vitro diagnostic (IVD) device for diagnosis of IgE-mediated drug allergies by building an integrated biophotonic system based on compact disc technology. For that, key enabling technologies will be integrated in order to achieve high sensitive (<0.1 kUA/L), selective (>98%), multiplexed (10 BLCs), rapid (30 min), and low-cost (2.4 €/allergen) drug allergy test. The solution involves an advanced approach to the diagnosis and management of drug allergy with the aim to ameliorate patient safety.
TORPIDO-2 Targeted Oxygenation in the Resuscitation of Premature Infants: Effects on Developmental Outcome – the TORPIDO2 Study.
- Call
- National Health and Medical Research Council (NHMRC), 2015.
- Investigador principal
- Dr. Máximo Vento
- Role
- Participant
- Year
- 2015
The TORPIDO 2 study is a pragmatic, randomised controlled trial (RCT) in infants between 23 weeks and 28 weeks 6 days gestation which aims to test one primary and two secondary hypotheses; that, compared with starting resuscitation with 60% oxygen and a targeted oxygen saturation (SpO2) strategy, starting resuscitation with room air (21% oxygen) and the same targeted SpO2 strategy will improve the survival without major disability at 2 years corrected for gestation.
WiBEC Wireless in-body environment communications.
- Call
- H2020-MSCA-ITN-2015-ETN.
- Investigador principal
- Dr. Vicente Pons
- Role
- Participant
- Year
- 2015
The main objective is to provide high quality and innovative doctoral training to develop the wireless technologies for novel implantable devices that will contribute to the improvement in quality and efficacy of healthcare.
EUToxRisk21 EUTOXRISK21. An Integrated EUropean ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century.
- Call
- H2020-PHC-33-2015-single-stage_RTD.
- Investigador principal
- Dr. José Vicente Castell Ripoll
- Role
- Participant
- Year
- 2015
The project will focus on repeated dose systemic toxicity (liver, kidney, lung and nervous system) as well as developmental/reproduction toxicity. EUToxRisk21 extensively integrates the adverse outcome pathway (AOP)-based toxicity testing concept, with advanced technologies, including high throughput transcriptomics, RNA interference, and high throughput microscopy, providing quantitative and mechanistic underpinning of AOPs and key events (KE). The project combines in silico tools and in vitro assays by computational modelling approaches to provide quantitative data on the activation of KE of AOP. This information, together with detailed toxicokinetics data, and in vitro-in vivo extrapolation algorithms forms the basis for improved hazard and risk assessment.
HERO Research Grant Cognitive - behavioural intervention program to improve adherence to prophylaxis and emotional state of patients with haemophilia.
- Call
- HERO (Haemophilia Experiences, Results and Opportunities) 2014.
- Investigador principal
- Dr. Santiago Bonanad
- Role
- Participant
- Year
- 2015
The aim of this project is to present and evaluate the effectiveness of a psychological intervention program developed in order to improve adherence to prophilaxys in adults patients with severe hemophilia.
The Gerber Foundation Efficacy of oro-pharyngeal mother’s milk: late-onset sepsis in LBW infants.
- Call
- The Gerber Foundation Grants 2014.
- Investigador principal
- Dr. Máximo Vento
- Role
- Participant
- Year
- 2015
The aim of this project is to compare the effects of oropharyngeal administration of mother's milk with buccal swabbing, to a placebo, for enhancing antioxidant defense maturation, or reducing pro-oxidant status in ELBW infants.
MDS-RIGHT Providing the right care to the right patient with MyeloDysplastic Syndrome at the right time.
- Call
- Horizon 2020, H2020- PHC-17-2014.
- Investigador principal
- Dr. Guillermo Sanz
- Role
- Participant
- Year
- 2015
The main objective of MDS-RIGHT is to develop more effective and safe interventions for elderly patients with anemia and/or low-risk of Myelodysplastic Syndrome (MDS) by analyzing the European database EUMDS (European MDS Registry).